Low-permeability reservoirs in Qiaokou gas field,Dongpu sag,features in large reserves and complica-ted geological conditions.By dint of SEM,X-ray diffraction,sensitivity testing,and other means,the author sums up factors of reservoir damages,specifies that the reservoirs in the study area mainly suffer from stress sensitivity,velocity sensitivity,water sensitivity,salt sensitivity,alkali sensitivity and acid sensitivity.Based on research and evaluation of all kinds of sensitivities,this paper presents approaches and solutions for maintaining the original reservoir permeability or enhancing reservoir permeability,and proposes practical measures for protecting low-permeability reservoirs and improving production performance.